NACI gratefully acknowledges the contribution of Ms. R. Hocking, Ms. A. Trivalent influenza vaccine and febrile adverse events in Australia, 2010: clinical features and potential mechanisms. 2000;7(1):29-40. H1N1: 41.7% L'épidémie s'est propagée sur tout le territoire métropolitain en quelques semaines pour atteindre son pic la première semaine de février. B: <0.001, Seroprotection rate supra) ; les personnes séjournant dans un établissement de soins de. TIV plus PCV7: 3.0 years Seroconversion rate B: 34.5 (28.8–41.3), Agrippal®, pre-vaccine GMT (95% CI) Extracted study data are presented in the evidence table in Appendix F for efficacy and effectiveness, Appendix G for immunogenicity and Appendix H for safety findings (confidential unpublished safety data provided by the manufacturerFootnote 2 are not summarized in the evidence table). A/Moscow/10/99-like Febrile with malaise/lethargy/irritability/headache: 12.0% Fluvax Junior®: 7.9 (5.3–11.8) To avoid the extraction of repetitive, duplicate, or redundant data, these publications were condensed and described under a single primary reference in the evidence tables. H3N2: 100.0% 1936 produzierte der Russe A. Uchaykin VF, Schamscheva OV, Novikova IN, Arzamasteva YY. B: 83.3%, Controls Children 6 months–4 years of age. One study from each of the three pairs of related studies was further identified as a primary reference for the present reviewFootnote 10 Footnote 12 Footnote 18. The study groups were similar with regard to age, sex and medical history. B: 802.2 (647–994), Agrippal®, post-vaccine GMT (95% CI) limit 19 to (english or french) [Expanding Pediatric Limit], Influenza, Human/pc [Prevention & Control], (Influenza, Human/ or exp influenzavirus a/ or exp influenzavirus b/) and exp vaccines/. Adverse events <36 months of age: 2 doses (0.25mL), 3–4 weeks apart, 36 months–13 years of age: 2 doses (0.5mL), 3–4 weeks apart, Strains Multiple Sklerose mit durch Infektionen getriggerten Schüben, angeborene oder erworbene Immundefizienz oder HIV). Schließlich geben die nationalen Behörden davon für den heimischen Markt bestimmte Impfstoffe frei. Im Vergleich zu den aktuellen Impfstoffen wird dabei für den nächsten Winter die Influenza A (H1N1)pdm09 Komponente verändert, berichtet das ECDC in einer Mitteilung. B: 100.0%, Controls (placebo-controlled), Follow-up Febrile with rigor: NA 2010. Safety and immunogenicity of two subunit influenza vaccines in healthy children, adults and the elderly: a randomized controlled trial in China. 2 doses (7.5 µg per strain), 28–42 days apart, Strains Pour vous abonner à vos sujets d'actualité préférés, vous devez être connecté(e) à votre espace personnel. B: 31.7 (24.8–40.4), Influvac®, post-vaccine GMT (95% CI) Influvac®: 2.7 years Jansen AG, Sanders EA, Smulders S, Hoes AW, Hak E. Adverse reactions to simultaneous influenza and pneumococcal conjugate vaccinations in children: randomized double-blind controlled trial. Fluvax Junior® TIV, Dose and administration Vaccine. Group A A double-blind RCT found Influvac® to be effective in reducing the risk of laboratory-confirmed influenza infection, incidence of febrile RTI, and acute otitis media among children aged 18–72 months with a previously reported physician-diagnosed RTIFootnote 18. B: 1.5, Seroprotection rate H3N2: 640 Ministerial review into the public health response into the adverse events to the seasonal influenza vaccine. B/Brisbane/60/2008-like, Population definition [7][8] Es gibt aber bisher keinen besseren medizinischen Schutz gegen Influenza. A/Wisconsin/67/2005 received “fair” ratingsFootnote 12 Footnote 18 Footnote 25. 26 and 27 [Flu Vaccine by Abbott or Solvay or BGP Pharma], 28 or 29 [Influvac or suspected Influvac], limit 30 to "all child (0 to 18 years)" [Limit not valid in Embase,Global Health; records were retained], exp Pediatrics/ or exp Infant/ or exp Child/ or Adolescent/, exp influenza viruses/ or influenzavirus a/ or influenzavirus b/, exp vaccination/ or exp vaccines/ or exp immunization/. B: 113.1, Group B Swelling: 12.8% H1N1: 1212.1 (982–1495) Design B/Beijing/184/93, Population definition A/California/7/2004 Influvac® TIV No SAEs were reported during the safety trial or the RCT. Systemic: 63.9% (117/183), TIV plus placebo, proportion with adverse event Influvac® TIV, Dose and administration [59][60][7], Bei Untersuchungen von 2010 bis 2017 zeigte sich, dass das Risiko, trotz Impfung durch das Virus infiziert zu werden, etwa drei bis fünf Wochen nach der Impfung am geringsten, die Schutzwirkung also am höchsten ist. B: 101, Unprimed A/New Caledonia/20/99 Die WHO empfiehlt dann üblicherweise für die Nordhalbkugel jeweils im Februar/März, für die Südhalbkugel jeweils im September eines Jahres auf Grund dieser Meldungen bestimmte Antigen-Kombinationen. B: 0.106, Seroprotection rate B: 1.2–2.7, GMFR [54], Das Deutsche Netzwerk Evidenz-basierte Medizin wies 2019 darauf hin, dass das Patientenrechtegesetz den Bürgern das Recht auf Aufklärung und informiertes Entscheiden zusichert. [79] 1942 wurde erstmals bivalenter Impfstoff aus inaktivierten Viren vom Typ A und Typ B in den USA lizenziert, in der allgemeinen Bevölkerung eingesetzt und in größeren Studien die Wirksamkeit nachgewiesen. (H3N2) BMJ Open. Correlates of protection against influenza have not been well established for other serological assessments, such as microneutralization assayFootnote 37 or neuraminidase inhibition assayFootnote 38, and therefore findings for these assays were not included in the present literature review. Der Corona-Boom bei Videosprechstunden und telefonischen Beratungen hat auch bei abflauender erster Welle angehalten. [77][78] Die Massenherstellung des Impfstoffs erfolgte zunächst durch die 1944 entwickelte Vermehrung in Hühnereiern, während die fünf Jahre später entwickelte Vermehrung in Zellkulturen noch keine Verwendung fand. Dann beschreiben Sie bitte in kurzer Form das Problem, die Redaktion wird diesen Kommentar genauer prüfen und gegebenenfalls löschen. Post-vaccination GMTs were not statistically significantly different between ALL patients and healthy controls for influenza A(H1N1) and B, but was statistically significantly lower in ALL patients for influenza A(H3N2) (p=0.041). Fever: 8 Parental report of medical attendance within 48hrs: 2.0%, Fluvax® H3N2: 44.7 Fatigue: 29.4% H3N2: 81.9 (55.8–120.0) Quality assessment was performed for the 17 published primary references included for review. Full-text screening of 92 records identified a total of 20 studies that were eligible for qualitative synthesisFootnote 7 Footnote 8 Footnote 9 Footnote 10 Footnote 11 Footnote 12 Footnote 13 Footnote 14 Footnote 15 Footnote 16 Footnote 17 Footnote 18 Footnote 19 Footnote 20 Footnote 21 Footnote 22 Footnote 23 Footnote 24 Footnote 25 Footnote 26. Local: 36.0% (67/186) Children aged 3–5 years (95% CI) Of the 20 published studies included for review, three were identified by handsearching the reference lists of relevant review articles retrieved through the database searchesFootnote 8 Footnote 12 Footnote 24. Immunogenicity and tolerability of a trivalent influenza subunit vaccine (Influvac) in high-risk children aged 6 months to 4 years. Pour recevoir gratuitement toute l’actualité par mail, AGRIPPAL, FLUARIX, IMMUGRIP, INFLUVAC et VAXIGRIP : extension de prise en charge des indications. H3N2: 100.0% Febrile and floppy/delirium: NA Ac Hematol Pol. In another multi-arm, pre-post study by Brydak et al. A/Moscow/10/99 TIV plus PCV7 vs. HBV plus placebo (control): 0.76 (0.58–0.99) 2000;7(1):21-7. TIV plus placebo vs. HBV plus placebo (control): 0.89 (0.50–1.61), Incidence rate (per 1000 days) (95% CI) Vos préférences de navigation ont bien été enregitrées. Of these 92 full-text articles, 72 full-text articles were excluded. Vous pouvez configurer vos réglages et choisir comment vous souhaitez que vos données personnelles soient utilisées en fonction des objectifs ci-dessous. Lymph node swelling: 3 B: 3.9, Controls Swelling: 13.0% B: 71% (49–87%), Seroconversion rate Sex H3N2: 27.1% Adverse events 3 days and 42 days post-vaccination, Population definition H1N1: 90.0% Das Bundesministerium für Arbeit, Soziales, Gesundheit und Konsumentenschutz veröffentlicht die Stellungnahmen des Nationalen Impfgremiums auch bezüglich Influenza. H3N2: 80.0% The lower limits of the 95% CI of the ratio of post-vaccination GMTs comparing Influvac® to Agrippal® for children aged 3–12 years (1.42–1.63), 3–5 years (0.94–1.29) and 6–12 years (1.44–1.70) were above the study-defined non-inferiority margin of 0.35, indicating that the immunogenicity of Influvac® was at least comparable to Agrippal® in these age groups. Lebensjahr, Betreuungspersonen (z. H1N1: 5.2 (4.8–5.6) Hemophiliac patients Total vaccinated with Influvac®: n=32, Adverse events following the first dose TIV plus PCV7 vs. HBV plus placebo (control): 0.73 (0.40–1.32) Vaccine (H3N2) 2001–2002 formulation: Br J Clin Pract. H1N1: 56.2% (26.9–73.1%) Design B: 6.2 (5.1–7.6), GMT post-vaccination (95% CI) Influenza Other Respir Viruses. H3N2: 50.0% Vitamin C bremst die Schäden der ROS an gesundem Gewebe. 2010 În farmaciile din România sunt deja disponibile vaccinurile antigripale. OR uncertainty in the evidence of advantages and disadvantages exists. Pediatr Infect Dis J. B: 100.0%, Controls Influenza vaccine Current methods of the US Preventive Services Task Force: a review of the process. Eine solche Anpassung wird … Healthy children 3–12 years of age, Study groups Triton X-100, Complete reactogenicity data was available for 56% of participants. The systemic adverse reactions recorded for TIV plus placebo, in descending order of incidence, were malaise, fever, headaches, and myalgia. (H3N2) Febrile with malaise/lethargy/irritability/headache: 0.70 (0.41–1.18) Study groups Febrile with rigor: 0.0% Children with chronic respiratory disease, congenital heart disease, or both. Durch mehrfache Impfungen kann außerdem eine Hühnereiweißallergie hervorgerufen werden.[64]. H3N2: 98.5% Use of ribomunil as combination prophylaxis of influenza and acute respiratory diseases in children. Incidence rate (per 1000 days) (95% CI) In a multi-arm pre-post study, Brydak et al. Eine solche Anpassung wird jedes Jahr wegen der veränderten zirkulierenden Virustypen nötig. El-Madhun et al. Brydak LB, Rokicka-Milewska R, Machala M, Klukowska A, Laguna P, Sikorska-Fic B. Efficacy of subunit trivalent influenza vaccine in previously vaccinated children suffering from hemophilia. B: 67.3, Controls H3N2: 54.0 (35.2–83.0) Vaccine. Unverändert bleiben hingegen die beiden Influenza-B-Komponenten im Grippe-Impfstoff: Ein B/Colorado/06/2017-ähnliches Virus der B/Victoria/2/87 Linie und ein B/Phuket/3073 /2013-ähnliches Virus der B/Yamagata/16/88 Linie. Laut Bericht für die Saison 2017/2018 lag die Wirksamkeit der Influenzaimpfung gegen den in der Saison 2013/2014 häufig zirkulierenden Subtypen A (H3N2) bei minus 66 % (-187 bis 17 %), Geimpfte waren also nicht etwa seltener, sondern deutlich häufiger mit diesem Virus infiziert als Ungeimpfte. H1N1: 35.8 B/Beijing/184/93-like, 2000–2001 formulation: A/Fuijan/411/2002 2010. Notes Mild to moderate pain: 0% Combined use of the Influvac vaccine and immunomodulator IRS-19 in the prophylaxis and treatment of viral respiratory infections. (eis). Jansen et al. Als Folge kann die Antigenität der schließlich auf den Markt kommenden Impfstoffe so stark von derjenigen der ursprünglichen Saat- und der zirkulierenden Wildviren abweichen, dass die Schutzwirkung des Impfstoffes verringert ist, wie Untersuchungen für den Subtyp A(H3N2) zeigten. Notwithstanding this new recommendation on the use of Influvac® (a TIV), NACI continues to recommend that a quadrivalent formulation of influenza vaccine be used for children younger than 18 years of age. Vaccine effectiveness against ILI was found to be 60.9% for children attending kindergartens, 68.8% for children attending schools, and 63.7% overall. (2008) conducted an endpoint-blind RCT in 300 healthy children 3–12 years of age, 300 healthy adults 18–59 years of age and 240 healthy elderly persons 60 years of age and older to assess the immunogenicity of Influvac® compared to another subunit TIV, Agrippal® (Seqirus; marketed in Canada as Agriflu®, in these age groupsFootnote 25. The protective response between the ALL and control groups for influenza A(H3N2) antigen did not differ significantly. Ethanol, Seroprotection rates were lower in vaccinated ALL patients (26.0–63.3%) than vaccinated healthy controls (73.0–88.0%), with a statistically significantly lower seroprotection rate for the H1N1 (p=0.04) and B (p=0.001) antigens. TIV plus placebo: 2.0 (1.4–2.7) unter die Haut (subkutan) gespritzt oder in die Nase gesprüht werden. Influenza vaccine Fatigue: 37.0% TIV plus PCV7: 41.4% female Headache: 0.9% H1N1: Not available 2 doses (7.5 µg per strain), 4 weeks apart, Strains In der Saison 2017/2018 kamen gemäß WHO-Empfehlung Dreifachimpfstoffe zur Anwendung, in denen der B/Phuket/3073/2013-ähnliche Stamm (Yamagata-Linie) des Influenza-Virus, der im Dreifachimpfstoff der Saison 2015/16 noch enthalten war, durch B/Brisbane/60/2008 ersetzt worden war. The effect of mass influenza immunization in children on the morbidity of the unvaccinated elderly. B: 26.0%, Controls, seroprotection rate Harris RP, Helfand M, Woolf SH, Lohr KN, Mulrow CD, Teutsch SM, et al. A/New Caledonia/20/99 There were no reports of febrile seizure for any of the vaccines. H3N2: 2.3 (1998), the immune response elicited by Influvac® was assessed in a group of hemophiliac patients aged 10–19 years who have been previously vaccinated against influenza (n=38) and compared to healthy controls who did not receive influenza vaccination during this study or previously (n=23)Footnote 11. H1N1: 76.4 (55.0–106.4) Euro Surv. B: 95% (91–98%), Agrippal ®, seroprotection rate (95% CI) Vaccinated with Influvac®: n=47. Extracted data for these three primary references were supplemented with non-duplicative findings from their respective related studies as indicated in Appendices F through H. After consolidation of studies with overlapping data sets, a total of 18 primary references were included in the present review, including 10 clinical trialsFootnote 9 Footnote 10 Footnote 11 Footnote 12 Footnote 16 Footnote 17 Footnote 18 Footnote 23 Footnote 25 Footnote 26, seven vaccine safety surveillance studies (Level III Evidence)Footnote 7 Footnote 8 Footnote 14 Footnote 15 Footnote 20 Footnote 21 Footnote 24, and one unpublished vaccine safety study by the manufacturer (Level III Evidence)Footnote 2. 2007–2008 formulation: Evidence from randomized controlled trial(s). Shahgholi E, Ehsani MA, Salamati P, Maysamie A, Sotoudeh K, Mokhtariazad T. Immunogenicity of trivalent influenza vaccine in children with acute lymphoblastic leukemia during maintenance therapy. H1N1: 8.3–10.0% A/Moscow/10/99 H3N2: 1.8 Systemic: 50.9% (88/173). Influvac® TIV, Dose and administration Children with ALL (groups A and B). Fluad®, Pediatric: public health need), Based on assessment of the body of evidence, Strong (H3N2) First, title and abstract information returned by the database searches were screened for potential eligibility. Healthy children without contraindications, Study groups Azerbaycan Metabolizm Jumali. H3N2: NR H3N2: 52.6% Voraussetzung sind ausreichend hohe Plasmaspiegel. Die Ursache sind vermutlich Antikörper gegen den Impfstoff. TIV plus placebo: n=187 Antimicrob Agents Chemother. B: 92.0%, Group B B: 50.0%, Seroconversion rate (H3N2) Available from: http://www.health.wa.gov.au/publications/documents/Stokes_Report.pdf. H1N1: 2.1 2010 formulation: 92 full-text articles were assessed for eligibility. B: 100.0%, Controls Seizures: 0 H1N1: 55.0% H1N1: 52.0% Parental reported fever: 45.2% Für die Saison 2019/2020 wurden durch das Paul-Ehrlich-Institut gemäß den Empfehlungen der WHO und der Bewertung durch das CHMP folgende Influenzaimpfstoffe zugelassen:[76]. 1996–1997 formulation: Une vaccination est nécessaire tous les ans. H3N2: 35.3 B: 59.4% (38.6–83.6%), Controls, post-vaccination (95% CI) H3N2: 40.6% (11.6–55.1%) ��8:�{\���r}���? Influvac® TIV (reported as a Solvay subunit TIV), Dose and administration The current recommendations on the choice of influenza vaccine currently available for use in Canada are summarized below by pediatric age group. ALL, seroprotection rate H3N2: 91.9 auftretenden anaphylaktischen Reaktion gesichert sind. The searches were restricted to articles published in English and French. En désactivant ces cookies, vous ne pourrez plus partager les articles depuis le site Vidal sur les réseaux sociaux. Controls: n=23, Age Fertilité . [26] Die bei der Schwangeren gebildeten Antikörper werden hierbei über die Placenta an das Ungeborene übertragen, so dass das Neugeborene bis zu einem Alter von weniger als sechs Monaten einen passiven Schutz hat (Nestschutz). Design Canadian Immunization Guide Chapter on Influenza and Statement on Seasonal Influenza Vaccine for 2017–2018 [Internet]. Epidemiol Infect. An updated summary of the characteristics of influenza vaccines available in Canada for the 2017–2018 influenza season can be found in Appendix A. B: 100.0%, Group B The publication chosen for the primary reference in these cases was defined as the publication containing the analysis that is most relevant to the objectives of the present systematic review.
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